Hiroyuki Kusuhara Selected Research

Multidrug Resistance-Associated Proteins

11/2013	Epigenetic regulation of organic anion transporting polypeptide 1B3 in cancer cell lines.
9/2013	Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.
3/2010	DNA methylation profiles of organic anion transporting polypeptide 1B3 in cancer cell lines.
12/2007	Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
11/2007	Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one).
1/2007	Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.

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Hiroyuki Kusuhara Research Topics

Disease

36	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2004
9	Neoplasms (Cancer) 01/2021 - 03/2010
7	Cholestasis 04/2024 - 02/2007
5	progressive familial intrahepatic 1 Cholestasis 01/2021 - 05/2014
4	Intrahepatic Cholestasis 12/2021 - 12/2015
4	Infections 05/2014 - 02/2007
3	Inborn Urea Cycle Disorders 12/2021 - 11/2019
3	Hypercholesterolemia 12/2019 - 12/2004
3	Pruritus (Itching) 02/2016 - 05/2014
2	Inflammation (Inflammations) 01/2024 - 10/2021
2	Neoplasm Metastasis (Metastasis) 01/2023 - 12/2013
2	Liver Diseases (Liver Disease) 01/2021 - 06/2016
2	Renal Insufficiency (Renal Failure) 01/2021 - 02/2007
2	Hepatocellular Carcinoma (Hepatoma) 12/2016 - 12/2013
2	Human Influenza (Influenza) 01/2014 - 02/2008
2	Tics (Tic) 05/2012 - 11/2010
2	Muscular Diseases (Myopathy) 12/2010 - 02/2009
2	Cerebral Infarction 11/2007 - 08/2007
2	Type 2 Diabetes Mellitus (MODY) 04/2003 - 08/2002
1	Necrosis 04/2024
1	Hepatitis 01/2024
1	Experimental Arthritis 01/2024
1	Arthritis (Polyarthritis) 01/2024
1	Diarrhea 12/2023
1	Fatty Liver 11/2023
1	Adenocarcinoma of Lung 01/2023
1	Chemical and Drug Induced Liver Injury 10/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2021

Drug/Important Bio-Agent (IBA)

38	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2003
9	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022 - 01/2005
6	4-phenylbutyric acid (Buphenyl)FDA Link 12/2021 - 05/2014
6	Multidrug Resistance-Associated ProteinsIBA 11/2013 - 01/2007
5	AnionsIBA 01/2020 - 02/2007
5	Peptides (Polypeptides)IBA 01/2020 - 02/2007
4	Bile Acids and Salts (Bile Acids)IBA 04/2024 - 12/2015
4	CholesterolIBA 01/2023 - 12/2013
4	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 06/2016 - 05/2008
4	Messenger RNA (mRNA)IBA 07/2015 - 10/2003
4	ATP-Binding Cassette Transporters (ABC Transporters)IBA 07/2012 - 01/2005
3	Adenosine Triphosphate (ATP)IBA 07/2012 - 01/2007
3	EstersIBA 05/2012 - 02/2008
3	Mitoxantrone (Novantrone)FDA LinkGeneric 06/2010 - 01/2005
3	Excipients (Suspending Agents)IBA 03/2009 - 07/2007
3	XenobioticsIBA 06/2008 - 01/2005
3	Hypoglycemic Agents (Hypoglycemics)IBA 02/2007 - 08/2002
2	Peptide Transporter 1IBA 01/2022 - 01/2021
2	EnzymesIBA 01/2022 - 12/2013
2	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 12/2019
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 10/2013
2	pitavastatin (itavastatin)FDA Link 10/2019 - 09/2005
2	DiureticsIBA 01/2019 - 08/2017
2	Therapeutic UsesIBA 06/2016 - 05/2014
2	sodium-bile acid cotransporterIBA 05/2014 - 08/2007
2	Oseltamivir (Tamiflu)FDA Link 01/2014 - 02/2008
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 09/2013 - 01/2012
2	2- amino- 3- (4- ((5- amino- 2- phenylbenzo(d)oxazol- 7- yl)methoxy)- 3,5- dichlorophenyl)propanoic acidIBA 09/2013 - 01/2012
2	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2013 - 07/2012
2	AcidsIBA 05/2012 - 11/2010
2	Pravastatin (Pravachol)FDA LinkGeneric 12/2010 - 02/2009
2	Multidrug Resistance-Associated Protein 2IBA 11/2010 - 07/2005
2	ProdrugsIBA 02/2008 - 04/2005
2	EdaravoneIBA 11/2007 - 08/2007
2	Free Radical ScavengersIBA 11/2007 - 08/2007
2	Sulfates (Sulfates, Inorganic)IBA 11/2007 - 06/2007
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2004 - 10/2004
2	Metformin (Glucophage)FDA LinkGeneric 04/2003 - 08/2002
2	BiguanidesIBA 04/2003 - 08/2002
1	Transaminases (Aminotransferases)IBA 04/2024
1	NF-kappa B (NF-kB)IBA 01/2024
1	factor XIIa inhibitor (INH(1))IBA 01/2024
1	LipopolysaccharidesIBA 01/2024
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2024
1	GalactosamineIBA 01/2024
1	pyrimidineIBA 01/2024
1	Collagen Type II (Type II Collagen)IBA 01/2024
1	AminesIBA 01/2024
1	Tyrosine Kinase InhibitorsIBA 12/2023
1	AfatinibIBA 12/2023
1	ErbB Receptors (EGF Receptor)IBA 12/2023
1	osimertinibIBA 12/2023
1	Choline (Choline Chloride)IBA 11/2023
1	Untranslated RNA (Noncoding RNA)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	OligonucleotidesIBA 01/2023
1	RNA (Ribonucleic Acid)IBA 01/2023
1	glutathione S-transferase M1IBA 10/2022
1	Glutathione Transferase (Glutathione S-Transferase)IBA 10/2022
1	UridineIBA 01/2022
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2022
1	Cytochrome P-450 CYP2C9IBA 01/2022
1	Carboxylesterase (Hydrolase S)IBA 01/2022
1	angiotensin I (1-7)IBA 10/2021
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 10/2021
1	Ribavirin (Virazole)FDA LinkGeneric 01/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 01/2021
1	Cefadroxil (Duricef)FDA LinkGeneric 01/2021
1	NucleosidesIBA 01/2021

Therapy/Procedure

6	Therapeutics 11/2023 - 01/2014
1	Oral Administration 12/2021